The analysis of biological defects of Autism by using autism mouse model.

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K10250
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Ritsumeikan University (2019); Shiga University of Medical Science (2016)
• Principal Investigator: Jin Nakatani 立命館大学, 生命科学部, 講師 (00342717)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 自閉症 / 疾患モデルマウス

Outline of Final Research Achievements

Autism Spectrum Disorder (ASD) is a pervasive developmental disorder defined by social and communication problems and emotional behavior. The etiology of the disease is unknown, even though there are various theories. In order to elucidate the biological pathogenesis of ASD, we developed a mouse model of ASD with the same genetic abnormalities as those frequently seen in human ASD patients, and examined the biological abnormalities. It turns out that this ASD mouse model has a serious developmental ploblems that causes more than 90 percent of its offspring to die shortly after birth. The few individuals that survived were able to reach adulthood despite their low growth, but at the same time they showed ADHD-like behaviors.

Free Research Field

神経生物学

Academic Significance and Societal Importance of the Research Achievements

本研究によりASDモデルマウスは発生学的に重篤な致死性を示し、９割以上の子供が途中で死んだ。この様に高い致死性を示すASDモデル動物はあまり報告がなく、ASDの生物学的異常を考える上で貴重なモデルであると言うことが可能である。また少数の生き延びたモデルであっても、注意欠陥、多動性障害(ADHD)様の行動を示した。ASDモデルで多動を示す様なモデルはあまりなく、ヒトADHDの病態を考える上で重要である、と考えられる。