2018 Fiscal Year Final Research Report

PET/MR evaluation of the relationship between estrogen receptor expression and oxidative stress in estrogen-dependent tumors

Research Project

PDF

Project/Area Number	16K10345
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Radiation science
Research Institution	University of Fukui
Principal Investigator	Tsujikawa Tetsuya 福井大学, 高エネルギー医学研究センター, 准教授 (30380033)
Co-Investigator(Kenkyū-buntansha)	前田浩幸福井大学, 学術研究院医学系部門, 准教授 (20301202) 森哲也福井大学, 高エネルギー医学研究センター, 助教 (40397287) 吉田好雄福井大学, 学術研究院医学系部門, 教授 (60220688)
Project Period (FY)	2016-04-01 – 2019-03-31
Keywords	PET/MRI / 酸化ストレス / エストロゲン / 乳癌 / 婦人科腫瘍
Outline of Final Research Achievements	We established the stable production method of Cu-64 ATSM which reflects oxidative stress, and confirmed the safety in acute toxicity tests using ddY mice. Whole-body PET/MRI with Cu-64 ATSM provided the distribution of the compound in healthy subjects. Intense Cu-64 ATSM uptake in liver was similar to that of F-18 FES (F-18 labeled compound of estradiol), and excretion to the intestine and urine was less than that of F-18 FES 60 min after the tracer injection. In a patient with ovarian cancer and multiple metastases, metastatic sites showed significantly higher Cu-64 ATSM uptake than the primary site which might reflect greater oxidative stress in metastatic sites than in the primary tumor.
Free Research Field	放射線医学
Academic Significance and Societal Importance of the Research Achievements	比較的長半減期（12.7時間）のCu-64で標識したATSMを用いることにより、１回のPET検査で全身の酸化ストレスの評価が可能である。複数の転移を有する腫瘍患者においても、病変全体の酸化ストレスに関する情報を得ることができ、今後はその集積程度や分布に応じた治療法の選択や新規治療法の開発に役立つ可能性がある。