Development of pump-based perfusion system using indwelling catheter to preserve hepatic-arterial flow after coil embolization of CHA for the treatment of postoperative hemorrhage after PD.

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K10364
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Teikyo University
• Principal Investigator: Furui Shigeru 帝京大学, 医療技術学部, 教授 (40114631)
• Co-Investigator(Kenkyū-buntansha): 近藤 浩史 帝京大学, 医学部, 教授 (20324311) ; 棚橋 裕吉 岐阜大学, 医学部附属病院, 助教 (40724563) ; 大澤 まりえ 帝京大学, 医学部, 助手 (10773161) ; 山本 敬洋 帝京大学, 医学部, 助手 (30621924) ; 五島 聡 岐阜大学, 医学部附属病院, 准教授 (90402205)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 膵癌 / 出血 / 塞栓術

Outline of Final Research Achievements

Postoperative hemorrhage by ruptured pseudoaneurysms after pancreaticoduodenectomy (PD) is a life-threatening complication. Transcatheter arterial embolization is effective but carries the risk of hepatic ischemia. We have developed a pump-based perfusion system using indwelling catheter to preserve hepatic-arterial flow after coil embolization of CHA. We evaluate the efficacy of this perfusion system in vitro and vivo. Favorable hepatic artery blood flow was obtained with a 6 Fr catheter and a pump setting pressure of 250 ml / min.
The pump-based perfusion system enables to preserve hepatic-arterial flow and more effective than the side-holed catheter system for post-PD hemorrhage.

Free Research Field

IVR

Academic Significance and Societal Importance of the Research Achievements

膵癌術後出血に対する新しい治療方法を開発した．出血に対する治療法としては動脈塞栓術があるが，肝動脈血流が温存できない可能性がある．また，ステントグラフトを用いれば肝動脈血流は温存できるが，すべての症例で留置可能とは限らない．今回のシステムを用いればこのような問題点を解決できる可能性がある．