Hybrid intervention for severe venous thromboembolism with stent-filter

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K10365
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nippon Medical School
• Principal Investigator: Tajima Hiroyuki 日本医科大学, 医学部, 教授 (00188244)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 静脈血栓塞栓症 / Intervention / Interventional Radiology / Thrombectomy / Aspiration

Outline of Final Research Achievements

The purpose of this research was to make a hybrid interventional therapy for severe venous thromboembolism with a newly-developed stent-filter. Development and fundamental research was achieved, but animal experiment was failed and difficult to move on to the clinical process. On the other hand, we retrospectively analyzed the late outcomes of hybrid catheter intervention, and showed that the 10-year survival rate was 74.5±9.0 %, by Kaplan-Mayer survival analysis, which was comparable with surgical embolectomy.

Free Research Field

放射線医学

Academic Significance and Societal Importance of the Research Achievements

重症静脈血栓塞栓症は、急性期死亡率が極めて高いため迅速で的確な診断と治療が不可欠である。治療として抗凝固療法、血栓溶解療法、外科的血栓摘除術が選択されてきたが十分な成果を得ているとは言えない。IVR(画像下治療)が注目されている。カテーテルからの新しい治療法で、我々のハイブリッドIVR治療はその完成形である。臨床応用に至り、成果を上げられれば重症患者の救命率の向上に大きな役割を果たす。