Graftr protection and preoperative viability estimation in Llver transplantation from donors after cardiac death

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K10430
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Ehime University
• Principal Investigator: Takada Yasutsugu 愛媛大学, 医学系研究科, 教授 (10272197)
• Research Collaborator: Ogawa Kohei ; Sakamoto Katsunori ; Tamura Kei
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 肝移植 / 心停止ドナー

Outline of Final Research Achievements

Use of liver grafts from donors after cardiac death (DCD) is one of the ways to attenuate the organ shortage in clinical liver transplantation (LT). To introduce the DCD-LT in Japan, we conducted a study of porcine LT using DCD as a translational research. As a results, porcine model of DCD-LT operation has been established. In addition, the efficacy of pharmacological graft protection has been suggested　in a rat DCD LT model.

Free Research Field

肝移植

Academic Significance and Societal Importance of the Research Achievements

本邦での現状において、DCD肝移植を行うとしてもしグラフト不全に陥った場合、再移植に必要なsecond liverが得られにくい。そこで本研究ではDCD肝移植を本邦において安全に臨床導入するための課題であるグラフト肝機能保護法と、移植前のグラフト肝viabilityの正確な評価法、の2つの確立をめざし、その可能性を示唆する成果が得られた。