2018 Fiscal Year Final Research Report
Identification of novel therapeutic target genes based on genomic progression model of colorectal cancer
| Project/Area Number |
16K10543
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
三森 功士 九州大学, 大学病院, 教授 (50322748)
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| Co-Investigator(Renkei-kenkyūsha) |
Niida Atsushi
Suzuki Yutaka
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 大腸癌 / 分子治療標的 / ゲノム進化 / がん遺伝子 |
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| Outline of Final Research Achievements |
Tumor heterogeneity is a major cause of the therapeutic difficulty of cancer due to the presence of multiple subclones boosting adaptation to pharmacologic interventions. We found several oncogenes as a potential therapeutic target in colorectal cancer to overcome the therapeutic resistance conferred by tumor heterogeneity.
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| Free Research Field |
腫瘍外科
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| Academic Significance and Societal Importance of the Research Achievements |
がん治療を困難としているがんの多様性に影響を受けない有効な治療標的となりうる遺伝子を複数同定しえた。現在それら遺伝子を標的とする治療薬（化合物）を開発を試みている。これらの成果はがん治療成績の向上に寄与するものと期待される。
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