2018 Fiscal Year Final Research Report
The impact of SP-D and ADAM17 on colitic cancer
| Project/Area Number |
16K10551
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鶴田 雅士 慶應義塾大学, 医学部(信濃町), 講師 (00348666)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 炎症性発癌 / SP-D / ADAM17 |
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| Outline of Final Research Achievements |
It is critical to clarify the molecular mechanism of colitic caner for improving the prognosis of ulcerative colitis. We have elucidated the impact of extra-pulmonary surfactant protein d (SP-D) on UC. This experiment aims for clarifying the correlation of SP-D with colitic caner.
Comparing SP-D knockout (KO) mouse and wild mouse by using colitic caner mouse model with dextran sulphate sodium and azoxymethane, higher incidence and more number of tumor were observed in SP-D KO mouse. Consequently, SP-D is suggested to play a role on colitic cancer.
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| Free Research Field |
大腸外科
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| Academic Significance and Societal Importance of the Research Achievements |
難治性炎症性腸疾患である潰瘍性大腸炎において，2次的に発症する炎症性発癌は予後に影響を与える問題点の1つであり，早期発見，発症予防は非常に重要である．本研究結果からSP-Dが潰瘍性大腸炎の病勢だけでなく，炎症性発癌にも関与していることが示唆され，例えばバイオマーカーや予防治療に応用することで，先述の課題解決に1筋の光を照らす可能性が期待できる．
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