2018 Fiscal Year Final Research Report
Analyses of regulatory B cell functions for tailor-made immunosuppression after liver transplantation
| Project/Area Number |
16K10575
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
調 憲 群馬大学, 大学院医学系研究科, 教授 (70264025)
吉住 朋晴 九州大学, 医学研究院, 准教授 (80363373)
池上 徹 九州大学, 大学病院, 講師 (80432938)
播本 憲史 群馬大学, 医学部附属病院, 講師 (00419582)
伊藤 心二 九州大学, 大学病院, 助教 (90382423)
副島 雄二 九州大学, 大学病院, 准教授 (30325526)
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Keywords | 肝移植 / 免疫寛容 / 調節性B細胞 |
|---|
| Outline of Final Research Achievements |
The aim of this study was to reveal the functions of regulatory B cells after liver transplantation. Eighteen patients who underwent living donor liver transplantation were divided into the tolerant (TOL) group (in which an intentional reduction of immunosuppressants was successfully achieved; n = 4) and the stable (STA) group (in which a certain amount of immunosuppressants was needed in order to prevent rejection; n = 14). Five healthy volunteers participated in this study (HV group). Lymphocytes were extracted from blood of these 18 patients and 5 healthy volunteers. Then, the percentages of regulatory B cells were compared among the 3 groups by flowcytometry. The percentage of regulatory B cells was the highest in the HV group, and the lowest in the STA group. The result suggested that regulatory B cells had an important role for immune tolerance after liver transplantation.
|
| Free Research Field |
肝移植
|
| Academic Significance and Societal Importance of the Research Achievements |
肝臓は他の臓器と比較して、免疫寛容状態を作りやすいことが、動物実験や実臨床で証明されており、その寛容形成に調節性T細胞やB細胞が大きく関与していることが示唆されている。臓器移植後の免疫抑制剤の長期使用は悪性腫瘍の発生、糖尿病や高血圧の発症、易感染性など様々な不利益をもたらす。免疫寛容状態の機序が解明されれば、臓器移植患者は長期の免疫抑制剤使用から開放され、さらなる生活の質の向上に役立つことが期待される。本研究では、健常者と比較して肝移植を受けた患者の調節性B細胞の割合が低下していることを明らかにした。本研究から、肝移植後のさらなる調節性B細胞の機能解明に繋がることが期待される。
|
