Glial metabolism evaluated by acetate positron emission computed tomography in chronic progressive brain ischemia model in rats

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K10713
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: University of Fukui
• Principal Investigator: Kikuta Kenichiro 福井大学, 学術研究院医学系部門, 教授 (90332725)
• Research Collaborator: Okazawa Hidehiko
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: ラット / 進行性脳虚血 / モデル

Outline of Final Research Achievements

Under general anesthesia by inhalation 1.5% isoflrene, bilateral vertebral arteries of 10-12 weeks old of Splague-Douley rats were coagulated and cut by bipolar coagualators. 2-3 days after, second operation was performed. Under general anesthesia, bilateral common, external, and internal carotid arteries were surgically exposed. Amyloid constrictor invented by Inohara et al was attached to right common carotid artery and contralateral internal carotid artery was ligated. Progressive hole brain ischemia could be obtained by this model but surgical mortality amounted to around 80%.

Free Research Field

脳血管障害

Academic Significance and Societal Importance of the Research Achievements

全脳モデルが作成できればもやもや病など進行性脳血管障害の治療に寄与すると考えられたが、本研究はモデルの致死率が高く、両側ではなく片側頸動脈の操作にモデルを変更して検討している。