Study for the pathogenesis of moyamoya disease from aspect of vascular shear stress and endothelium

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K10728
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Saga University
• Principal Investigator: Matsuo Muneaki 佐賀大学, 医学部, 教授 (20219398)
• Co-Investigator(Kenkyū-buntansha): 江良 択実 熊本大学, 発生医学研究所, 教授 (00273706) ; 北川 裕之 神戸薬科大学, 薬学部, 教授 (40221915) ; 島野 健仁郎 東京都市大学, 工学部, 教授 (90287475)
• Research Collaborator: Inoue Kouhei ; Serigaya Syota ; Nadanaka Satomi ; Soga Minami
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: もやもや病 / 多能性幹細胞 / 血流剪断応力 / 血管内皮細胞 / 細胞外マトリックス

Outline of Final Research Achievements

We demonstrated changed extracellular matrix of vascular endothelial cells in moyamoya disease. Extracellular matrix of vascular endothelium play an impotent role in protect endotheium against vascular shear stress. Thus, in moyamoya disease, vascular endothelium could become vulnerable to vascular shear stress. Since stenotic lesions in moyamoya disease exists in region where shear stress is high, endothelial damage would be caused first, then progressive thickening the vascular intima and narrowing the vascular lumen would occur during repair process.

Free Research Field

小児神経学

Academic Significance and Societal Importance of the Research Achievements

本研究成果により、もやもや病の病態を明らかにすることができた。今後の治療介入のための新しい標的を定めることが可能となり、新しい治療法の開発につながると思われる。