Amelioration in the regenerative capacity of aged skeletal muscle by pro-IGF-II signal

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K10881
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: UEZUMI MADOKA (池本円) 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (70435866)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 老化 / 骨格筋 / 再生

Outline of Final Research Achievements

Sarcopenia, age-related muscle weakness, increases the frequency of falls and fractures in elderly people, which can trigger severe muscle injury. Rapid and successful recovery from muscle injury is essential not to cause further frailty and loss of independence. We previously reported that supplementation of pro-insulin-like growth factor-II (pro-IGF-II) ameliorates age-related inefficient regenerative response. However, it is expected to develop a more safety and specific therapeutic strategy for clinical application due to the tumor promoting activity of pro-IGF-II. In this study, we analyzed pro-IGF-II signal in mesenchymal progenitors and found the candidate factors that suppress adipogenic differentiation and do not have tumor promoting activity. Administration of the candidate factors could be the effective therapeutic strategy for muscle injury in elderly people.

Free Research Field

筋生物学

Academic Significance and Societal Importance of the Research Achievements

高齢者において転倒や骨折に伴う筋損傷からの回復の遅れは、要介護への進行原因となり、健康寿命延伸のために解決すべき重要課題である。しかしながら、現在、老化筋の再生能力を改善する方法はない。本研究では、我々が老化筋の再生能力改善効果を見出したpro-IGF-IIに着目し、そのシグナルパスウェイ解析から、より安全で特異的な治療のための候補因子を同定した。この因子の投与は高齢者の筋再生能力改善のためのより安全な治療法となる可能性がある。