Inhibitory effect of the multiple receptor tyrosine kinase inhibitor on osteoarthritis

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K10919
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Tokai University
• Principal Investigator: NAGAI Toshihiro 東海大学, 医学部, 講師 (20514376)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 関節軟骨修復 / 変形性関節症 / 血管新生阻害剤

Outline of Final Research Achievements

We investigated the efficacy of a multiple receptor tyrosine kinase (mRTKs)inhibitor which was developed in Japan, in the treatment of osteoarthritis (OA) using a rabbit model of ACLT.　mRTKs had no negative effect (e.g., diarrhea and vomiting) in normal rabbits. Histologically, administration of mRTKs group exhibited a reduction in articular cartilage degeneration and less osteophyte formation and synovitis compared with the control group (OA group). And assessment of pain behavior showed a superior effect in the administration of mRTKs group compared with the OA group 12 weeks after administration of mRTKS.

Free Research Field

整形外科

Academic Significance and Societal Importance of the Research Achievements

変形性関節症(OA)はその進行予防が極めて重要であるが、末期OAに至るまでの初期から中等度OAに対する薬物療法は、疼痛改善を主眼としており軟骨変性を抑制し疾患の進行を抑止しうるには至らず、OAの進行が余儀なくされている。mRTKs inhibitorは疼痛改善効果のみならず、良好な関節軟骨修復効果（軟骨変性抑制効果と滑膜炎抑制効果と骨棘形成抑制効果）が見込まれ、病勢を抑止する可能性がある新規の治療法である。