Pathophysiology of pregnancy induced hypertension using transcriptome analysis by RNA-Seq

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K11117
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Fujita Health University
• Principal Investigator: NISHIZAWA HARUKI 藤田医科大学, 医学部, 教授 (80367698)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: pre-eclampsia / placenta / RNA sequencing

Outline of Final Research Achievements

Pregnancy induced hypertensive is known as one of the serious diseases in the perinatal area, but no effective treatment has been established. In this study, when the placenta of pregnancy induced hypertensive was analyzed by RNA sequencing, which is a new transcriptome analysis using a next-generation sequencer, it was possible to identify novel transcripts and splicing variants. New findings obtained from the results of this study are expected to contribute significantly to the development of diagnostic and therapeutic methods for the pathogenesis of pregnancy induced hypertension and placental hypoplasia.

Free Research Field

産科学

Academic Significance and Societal Importance of the Research Achievements

妊娠高血圧症候群は，周産期領域における重篤な疾患の一つとして知られていますが，発症機序や予防法は確立されていません。今回，遺伝子の塩基配列を高速に読み出せる最新の次世代高速シークエンサーという装置を用いて解析を行ったところ，これまでの研究では明らかとなっていない遺伝子産物や翻訳過程を明らかにすることが可能でした。本研究結果から，妊娠高血圧症候群や胎盤形成不全の発症機序が明らかにされるとともに新たな診断および治療法の開発が期待されます。