2019 Fiscal Year Final Research Report
Functional analysis of retinoic acid signaling in ovarian cancer
| Project/Area Number |
16K11130
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Keywords | 卵巣癌 / シグナル伝達 / 治療標的 |
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| Outline of Final Research Achievements |
High expression of Pin1 in ovarian tumor tissues was correlated with histological type (serous cancer) and clinically advanced stage (II to IV stage). In a multivariate analysis of factors affecting progression-free survival in 45 non-serous cancers, clinical stage and high Pin expression were extracted as independent poor prognosis factors. The antitumor effect of Pin1 inhibitors was verified in cultured cell lines. The antitumor effect at low concentration was confirmed in SKOV3 and EGCG, OVSAHO and Juglone, respectively. These results suggest that Pin1 may be one of the target molecules for ovarian cancer treatment.
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| Free Research Field |
婦人科腫瘍学
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| Academic Significance and Societal Importance of the Research Achievements |
上皮性卵巣癌においてPin1の高発現は予後不良因子となること、特に非漿液性癌においては独立した予後不良因子となることが示された。卵巣漿液性癌培養細胞系において低濃度でのPin1阻害剤で殺細胞効果が確認された。Pin1は卵巣癌治療の標的分子の1つになりうることが示唆された
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