Neural Network Regeneration using Skeletal Muscle-Derived Multipotent Stem Cell

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K11248
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Tokai University
• Principal Investigator: OKAMI Kenji 東海大学, 医学部, 教授 (90223734)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 骨格筋間質幹細胞 / 神経ネットワーク / QOL

Outline of Final Research Achievements

Nerve resection animal model was established and extremities and joint movements were observed. A skeletal muscle-derived multipotent stem cells (Sk-MSCs) were developed and transplanted to the injured lesion and the differentiation into neural cells were observed. Secretory cytokines in the culture supernatant were analyzed and the effect to the regeneration were evaluated. Muscle tonus, weight, and histochemical changes were investigated. The effect for regeneration of the cytokine cocktail were analyzed.

Free Research Field

再生医療科学

Academic Significance and Societal Importance of the Research Achievements

治療によって失われた機能を、幹細胞移植による再生医療で回復させ、幹細胞移植なしに神経ネットワークが再生されれば、低侵襲かつ拒絶反応のない機能再生が実現できる。さ倫理的問題も少なく臨床応用が可能であり、治療後の患者のQOL（生活の質）を改善させる大きな福音となる。