Practice algorithm of the REM-related sleep apnea

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K11251
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: Kitamura Tarkuo 産業医科大学, 医学部, 准教授 (60341509)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: レム関連睡眠時無呼吸 / 睡眠呼吸障害 / 睡眠時無呼吸症候群 / 閉塞性睡眠時無呼吸

Outline of Final Research Achievements

The REM related obstructive sleep apnea (REM-OSA) is one of the subtypes to account for 10-36% of the whole obstructive sleep apnea (OSA) patients and is clinical condition that respiratory events concentrates during REM sleep. As a result of this study, (1) CPAP adherence was low in the REM-OSA group, moreover, improvement of daytime sleepiness was poor in the REM-OSA group. (2) Nasal surgery is more effective for REM_AHI than for NREM_AHI. Although nasal surgery alone does not have a consistent effect on SDB. Meanwhile, the pharynx extended surgery is more effective for NREM_AHI than for REM_AHI. (3) The elderly people 65 years or older showed a correlation between REM_AHI and nasal cavity resistance level, and a nasal cavity resistance level was significantly higher in REM_OSA of elderly people.

Free Research Field

睡眠呼吸障害

Academic Significance and Societal Importance of the Research Achievements

１）レム関連睡眠時無呼吸に対するCPAPの効果: CPAP治療開始後の90日間の解析で、レム関連睡眠呼吸障害群ではアドヒアランス（１夜あたりの使用時間が４時間以上の割合）、エプワース眠気尺度（ESS）の改善度が有意に低値であった。１）レム関連睡眠時無呼吸に対するCPAPの効果: CPAP治療開始後の90日間の解析で、レム関連睡眠呼吸障害群ではアドヒアランス（１夜あたりの使用時間が４時間以上の割合）、エプワース眠気尺度（ESS）の改善度が有意に低値であった。