Assessment of genetic factors associated with surgical effects in primary open-angle glaucoma

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K11267
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: Akagi Tadamichi 京都大学, 医学研究科, 准教授 (30580112)
• Co-Investigator(Kenkyū-buntansha): 中西 秀雄 京都大学, 医学研究科, 助教 (80724278)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 緑内障 / 流出路再建術 / 遺伝因子

Outline of Final Research Achievements

In recent years, minimally invasive glaucoma surgery (MIGS) has become a popular first-line surgery worldwide. Intraocular pressure reduction targets and expected success rates were not very different between the MIGS and the classic trabeculotomy.
It was examined whether genetic factors, such as TMCO1, CAV1/CAV2, CDKN2B-AS1, ABCA1, SIX1/SIX6, and LOXL1, were associated with the surgical effects in 377 cases. However, the results were not significant and it might be difficult to use single-nucleotide polymorphism (SNP) as a marker for postoperative outcomes.

Free Research Field

緑内障

Academic Significance and Societal Importance of the Research Achievements

最近の小切開低侵襲緑内障手術が従来のものとおよそ同程度の手術効果が期待できることが確認できたことは、今後も小切開手術を施行していくうえで意義の大きい結果といえる。今回の結果からは緑内障手術の流出路再建術の術後成績を遺伝因子で予測することは困難であることが示唆された。