BDNF in the anterior chamber and serum blood in glaucoma patients

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K11276
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Nippon Medical School
• Principal Investigator: Kenji Nakamoto 日本医科大学, 医学部, 講師 (30287734)
• Co-Investigator(Kenkyū-buntansha): 高橋 浩 日本医科大学, 大学院医学研究科, 大学院教授 (00188046) ; 五十嵐 勉 日本医科大学, 医学部, 准教授 (10421190)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 緑内障 / 神経保護因子 / BDNF

Outline of Final Research Achievements

There are a number of glaucoma patients who progress the disease despite the decrease of intraocular pressure. Retinal ganglion cell death has long been focused on neuroprotective factors such as BDNF, and its usefulness has been reported in animal experiments. However, the distribution or amount of BDNF in the eye of a glaucoma patient is unknown. In this study, it is intended to determine whether BDNF is reduced in glaucoma, and if there is a change in the amount, whether the change correlates with the change in blood concentration. Moreover, from this result, we will examine whether it is possible to apply gene therapy using BDNF in the future.

Free Research Field

緑内障

Academic Significance and Societal Importance of the Research Achievements

緑内障は失明第一位の疾患であり、少しでも失明を防ぐことは急務であり、高い学術的意義と社会的意義があると考えられる。