2018 Fiscal Year Final Research Report
Development of contact lens new design for myopia control based on higher-order aberration theory
| Project/Area Number |
16K11316
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 近視 / 高次収差 / コンタクトレンズ / 調節 / 視機能 / 眼軸長 |
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| Outline of Final Research Achievements |
We accumulated a large set of clinical data from myopic schoolchildren, and analyzed those in detail. As a result, a close relationship between some components of higher-order aberrations (HOA) and myopia progression (axial elongation) was observed. These findings were reported as a scientific article (Hiraoka T, et al. Relationship between higher-order wavefront aberrations and natural progression of myopia in schoolchildren. Sci Rep. 2017).
In addition, we experimentally produce a specially-designed soft contact lens (SCL) with appropriate amounts of HOA. Eight normal volunteers wore the lens, and various examinations were performed. The SCL significantly reduce accommodative responses for near sight and accommodative microfluctuations. This indicated that the specially-designed lens can decrease accommodative burden and ocular fatigue especially at near work.
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| Free Research Field |
眼光学
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| Academic Significance and Societal Importance of the Research Achievements |
一連の研究により，高次収差の増加が調節負荷の軽減を介して近視進行や眼軸長伸長に抑制的に働くというメカニズムの一部を証明することができた．この光学メカニズムを最大限に利用することにより，非常に有効な近視進行抑制法の臨床応用が実現できる可能性が広がり，将来的な病的近視や近視関連合併症の発生を減少させるという観点から，その医学的・社会的意義は極めて大きいと考えられる．
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