2018 Fiscal Year Final Research Report
Role of Neurovascular unit regulated by amacrine cells in refractory inflammatory eye diseases
Project/Area Number |
16K11330
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | Tokyo Medical University |
Principal Investigator |
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Keywords | ぶどう膜炎 / Neurovascular unit |
Outline of Final Research Achievements |
Because retinal amacrine cells and horizontal cells are present in the vicinity of intraretinal capillaries in the intermediate and deep plexuses, the amacrine cells and horizontal cells interact with the capillaries in the intermediate and deep plexuses of the retina and may contribute to stabilization of the vasculature. BRB failure causes damage to capillaries in the inner plexus of the retina due to functional failure of amacrine cells and horizontal cells present in the inner plexus of the retina. These are speculated to result in edema and visual function deterioration in inflammatory eye diseases.
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Free Research Field |
眼科学
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Academic Significance and Societal Importance of the Research Achievements |
Neurovascular unitは網膜疾患病態解明でも治療の面でも重要であり、神経および血管障害をきたす眼炎症性疾患では、アマクリンニューロンが制御するNeurovascular unit全体を治療標的とし、網膜血管の破綻を救済するneurovascular protectionという新たなコンセプトで、難治性眼炎症疾患以外の様々な網膜疾患(糖尿病網膜症、網膜静脈閉塞症、加齢黄斑変性症、未熟児網膜症など)の治療法も開発される可能性がある。
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