Developing the model using pH/calcium fluorescent imaging for prevention and treatment of dental caries

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K11540
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Tohoku University
• Principal Investigator: MAYANAGI Gen 東北大学, 歯学研究科, 助教 (10451600)
• Co-Investigator(Kenkyū-buntansha): 鷲尾 純平 東北大学, 歯学研究科, 講師 (20400260) ; 高橋 信博 東北大学, 歯学研究科, 教授 (60183852) ; 佐藤 拓一 新潟大学, 医歯学系, 教授 (10303132)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 細菌 / pH / カルシウム / エナメル質齲蝕 / 根面齲蝕 / フッ化物徐放性歯科材料 / インターフェイス

Outline of Final Research Achievements

This study aimed to develop the methods to assess pH change at the interface　between material or tooth and bacteria continuously under the same kind of conditions as an oral microenvironment in vitro. The fluoride releasing materials and the silver diamine fluoride coated tooth inhibited pH fall at the interface between material/tooth and bacteria. The degree of inhibition of pH fall seemed to correspond to the amounts of fluoride and silver detected, suggesting that the fluoride and silver released from these materials inhibited pH fall.

Free Research Field

口腔生化学、保存修復学、歯周病学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、歯面や歯根面の詳細な脱灰メカニズムの解明に寄与するものであり、齲蝕の予防・治療に効果のある歯科材料・食品・薬剤等の評価や開発に応用が可能なことに加えて、より精度の高い齲蝕の基礎研究・臨床研究への展開が期待できる。