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2018 Fiscal Year Final Research Report

The analysis of pd-1/pd-l1 pathway in 4NQO induced rat tongue cancer model

Research Project

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Project/Area Number 16K11681
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionGifu University

Principal Investigator

yonemoto kazuhiro  岐阜大学, 医学部附属病院, 助教 (80422731)

Co-Investigator(Kenkyū-buntansha) 柴田 敏之  岐阜大学, 大学院医学系研究科, 教授 (50226172)
牧田 浩樹  岐阜大学, 大学院医学系研究科, 講師 (50345790)
Project Period (FY) 2016-04-01 – 2019-03-31
Keywords口腔ガン / 4nqo舌癌ラットモデル / PD-1/PD-L1経路
Outline of Final Research Achievements

Nivolumab has been sold in japan.Although adaptation to oral cancer has been expanded,PD-1/PD-L1 pathway In oral carcinogenesis was still unknown.We aimed to analyze the abnormal expression of PD-L1 in 4NQO induced rat tongue cancer model.We used resection specimens of rat tongue cancer model and measured the expression level of PD-L1.We demonstrated that the control group was not observed PD-L1 expression, but abnormal expression of PD-L1 in tongue cancer group

Free Research Field

口腔ガン

Academic Significance and Societal Importance of the Research Achievements

本研究により、4NQO誘発ラット舌癌モデルにおけるPD-L1の発現異常を明らかにした。今研究の結果は、今後更に発展すると思われる免疫療法の分野において、動物モデルで確認することも可能となり、口腔癌治療に有効な口腔発癌抑制物質の新たな開発につながるものと考えられ、意義は非常に高いと考える。

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Published: 2020-03-30  

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