Relationship between Sjogren's syndrome and intestinal flora and intestinal immunity

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K11690
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: OHYAMA YUKIKO 九州大学, 大学病院, 講師 (70294957)
• Co-Investigator(Kenkyū-buntansha): 森山 雅文 九州大学, 歯学研究院, 助教 (20452774) ; 梶岡 俊一 九州大学, 医学研究院, 准教授 (90274472)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: シェーグレン症候群 / IgG4関連涙腺・唾液腺炎 / 腸内細菌叢

Outline of Final Research Achievements

In Sjogren's syndrome (SS), the relationship between transcription factors and cytokine expression and lymphocyte infiltration suggests that Th2 cells are involved in the progression of disease and can be applied as biomarkers for diagnosis and disease progression. Similarly, it was suggested that Tfh cells are involved in the pathogenesis of IgG4-related lacrimal glands and salivary glands.
It was suggested that the analysis and comparison of the intestinal microbiota of SS should analyze the relationship with changes in these biomarkers.

Free Research Field

口腔外科学

Academic Significance and Societal Importance of the Research Achievements

シェーグレン症候群、IgG4関連涙腺・唾液腺炎患者の腸内細菌叢の解析においては、診断および病勢のバイオマーカーを指標に分類、検討していくことが必要であることがわかり、今後の研究の方向性となった。