2018 Fiscal Year Final Research Report
Study of salivary gland regeneration by stem-like cell and organ culture.
| Project/Area Number |
16K11714
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
池邉 哲郎 福岡歯科大学, 口腔歯学部, 教授 (20202913)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 唾液腺 / 再生 / 分化 |
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| Outline of Final Research Achievements |
We investigated the involvement of some growth factors, such as EGF, FGF, KGF and HGF, in growth and regeneration in irradiated salivary gland. These growth factors promote branching morphogenesis and amylase expression in salivary gland of embryonic day 12.5 mouse. We suggested EGF and FGF7/10 could recover decreased ability of growth and functions of irradiated salivary gland.
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| Free Research Field |
外科系歯学
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| Academic Significance and Societal Importance of the Research Achievements |
放射線療法は口腔癌の標準治療の1つで、その有効性は高く必要不可欠なものである。しかし効果とは反面、晩期障害として口腔乾燥が高頻度で出現し、治療の遂行や治療後のQOLに大きな影響を及ぼす。唾液腺の機能低下は重要な問題であるが、修復・再生の確立は得られていない。その障害された唾液腺の修復・再生のメカニズムを解明することは、口腔乾燥という合併症を軽減し、QOLの向上が期待される点で学術的・社会的意義は大きい。
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