2019 Fiscal Year Final Research Report

Bone regenerative enhancement effect of octacalcium phosphate collagen composite combined with bone formation promoter

Research Project

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Project/Area Number	16K11741
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Surgical dentistry
Research Institution	Tohoku University
Principal Investigator	MATSUI KEIKO 東北大学, 歯学研究科, 助教 (00302159)
Co-Investigator(Kenkyū-buntansha)	鎌倉慎治東北大学, 医工学研究科, 教授 (80224640) 高橋哲東北大学, 歯学研究科, 教授 (60226850) 川井忠岩手医科大学, 歯学部, 講師 (50547263)
Project Period (FY)	2016-04-01 – 2020-03-31
Keywords	リン酸カルシウム系生体材料 / リン酸オクタカルシウム（OCP) / OCP/collagen 複合体 / 骨再生材料 / 骨形成促進薬 / テリパラチド / ビーグル犬 / 下顎骨離断
Outline of Final Research Achievements	A synthetic parathyroid hormone (Teriparatide), which is a therapeutic drug for osteoporosis, was used to enhance the bone regenerative ability of the bone substitute material OCP/Collagen composite (OCPCol) and to evaluate the bone regeneration status. The mandibular bones of five Beagle dogs were resected with a width of 15 mm, a size that would not be able to heal naturally. OCPCol disks combined with Teriparatide were implanted into the prepared bone defects and observed for 6 months. Radiopaque regions were confirmed radiographically in the mandibular dissection after 1 to 2 months, and sufficient amount of bone bridges were formed in 6 months. The continuity of the resected mandibular bone was restored in all cases. In the oral cavity, the jaw ridges of the resected regions were restored to the pre-operative status. Therefore, we confirmed that bone regeneration using OCPCol in combination with Teriparatide could be helpful for clinically.
Free Research Field	外科系歯学
Academic Significance and Societal Importance of the Research Achievements	口腔外科領域の顎骨再建では腸骨や腓骨等自家骨が移植されるが，骨採取の二次的外科侵襲の回避，採骨量の制限解除を目標として材料単独使用による顎骨再建が希求される．OCP/Collagen複合体（OCPCol）は，厚生労働省より製品化承認済であり，その骨再生能は各種人工的骨欠損モデルによって検証してきたが，イヌ下顎骨離断部位へのOCPCol単独埋入において，顎骨の連続性回復状態が不安定であった．今回，骨粗鬆症治療薬のテリパラチド併用により100%の確率で骨再生が確認できたことは，骨再生材料と薬剤併用という簡便な方法での顎骨再建の可能性を実証したものであり，ヒト臨床応用上の利益となり意義がある．