Role of complement factor B on insulin resistance-related disease

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K11835
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: Kyushu University
• Principal Investigator: Iwashita Misaki 九州大学, 歯学研究院, 助教 (80611326)
• Co-Investigator(Kenkyū-buntansha): 浅野 知一郎 広島大学, 医歯薬保健学研究科(医), 教授 (70242063) ; 山下 明子 九州大学, 歯学研究院, 助教 (70511319) ; 西村 英紀 九州大学, 歯学研究院, 教授 (80208222)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 脂肪細胞分化 / CfB / 脂肪蓄積

Outline of Final Research Achievements

Complement factor B (CfB) is one of the complement system-related molecules. In CfB-overexpressing 3T3-L1 cells, the expression of adipocyte differentiation/maturation-related genes encoding peroxisome proliferator-activated receptor γ (Pparγ), adipocyte Protein 2 and perilipin was significantly enhanced. Adipocyte-specific CfB overexpressing (CfB Tg) mice showed increased body weight and impaired insulin sensitivity. Furthermore, in CfB Tg mice, we observed a marked increase in the expression of genes encoding Pparγ, perilipin, sterol regulatory element-binding protein 1 c and Cd36 in the subcutaneous adipose tissue compared to wild type mice.
Our findings indicate that CfB plays a crucial role in late-phase of adipocyte differentiation and subsequent lipid droplet formation.

Free Research Field

歯周病学

Academic Significance and Societal Importance of the Research Achievements

補体調節因子の一つであるCfBが脂肪細胞の分化・成熟，脂肪蓄積を促進し肥満およびインスリン抵抗性の増悪に関与することを明らかにしたことにより、CfBの肥満およびインスリン抵抗性に対する治療標的としての新たな可能性を見出した。その研究成果は国際科学雑誌Biochemical and Biophysical Research Communicationsに掲載された。