2017 Fiscal Year Final Research Report
Can colonic hydrogen derived from non-digestible saccharides substitute for ascorbic acid as an electron donor in vivo?
| Project/Area Number |
16K12719
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Shizuoka University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 水素 / 大腸発酵 / 抗酸化作用 / 難消化性糖質 / α-トコフェロール / アスコルビン酸 |
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| Outline of Final Research Achievements |
Hydrogen molecule, which is produced by colonic fermentation of non-digestible saccharides, show the reducibility in vivo and then contribute to inhibited inflammation. Hydrogen have been reported to scavenge a potent reactive oxygen species, hydroxyl radical, in vitro. However, it remains unclear whether it will act by the same mechanism in vivo. In this study, we found that colonic hydrogen alleviates oxidative stress by promoting the regeneration of α-tocopherol as an electron donor in the adipose tissue. Hydrogen is a nonpolar molecule and its redox potential is very low, so the effect in adipose tissue is reasonable.
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| Free Research Field |
栄養化学
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