Obesity induced by collapsed feeding rhythm

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K12746
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: National Agriculture and Food Research Organization
• Principal Investigator: OIKE Hideaki 国立研究開発法人農業・食品産業技術総合研究機構, 食品研究部門, 主任研究員 (30455307)
• Co-Investigator(Renkei-kenkyūsha): ISHIMARU Yoshiro 東京大学, 大学院農学生命科学研究科, 特任准教授 (10451840)
• Research Collaborator: OISHI Katsutaka 国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, グループ長
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 概日リズム / 時間栄養学 / 体内時計 / シフトワーク / マウス / 肥満 / 時差ボケ

Outline of Final Research Achievements

In this study, we analyzed effects of light/dark- or feeding/fasting- pattern on body weight, energy metabolism, and circadian clocks of peripheral tissues in mice. As a result, periodic advance of light/dark cycle efficiently increased body weight gain. Under this light/dark condition, the body weight gain was correlated with decrease of circadian amplitude of respiratory quotient fluctuation and also correlated with glucose usage. It was suggested that collapse of circadian feeding rhythm due to irregular activity pattern caused suppression of lipid usage, leading to obesity.

Free Research Field

時間栄養学