Model experiments of partial pressure of oxygen-guided intensity modulated radiation therapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K12862
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Hokkaido University
• Principal Investigator: Hirata Hiroshi 北海道大学, 情報科学研究科, 教授 (60250958)
• Co-Investigator(Renkei-kenkyūsha): MATSUMOTO Shingo 北海道大学, 大学院情報科学研究科, 准教授 (90741041)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 腫瘍 / 放射線 / 酸素分圧 / 画像

Outline of Final Research Achievements

The purpose of this study was to clarify the outcomes of the model experiments of oxygen partial pressure-guided radiation therapy. A miniature multi-leaf collimator (MLC) was developed for the model experiments using tumor-bearing mice. This miniature MLC was planned to control the intensity and the distribution of X-ray irradiation to tumor model mice. Also, the computation method for obtaining the collimator opening from the three-dimensional data of oxygen partial pressure in mouse tumors was developed and implemented. Moreover, tumor-growth curves were obtained for non-treated and uniform X-ray irradiated mice. These data will be the control data of tumor growth. For preparing tumor-bearing mice, murine squamous cell carcinoma (SCC VII) cells were subcutaneously implanted in mouse hind legs.

Free Research Field

計測工学