Study on a mechanical memory of the intracelualr forces and stractures

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K12865
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Ibaraki University
• Principal Investigator: Nagayama Kazuaki 茨城大学, 工学部, 教授 (10359763)
• Co-Investigator(Renkei-kenkyūsha): MATSUMOTO TAKEO 名古屋大学, 大学院工学研究科, 教授 (30209639) ; SUGAWARA MICHIKO 千葉大学, 大学院工学研究科, 准教授 (30323041)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 細胞骨格 / 細胞核 / メカノバイオロジー / 細胞計測・操作

Outline of Final Research Achievements

We investigated the mechanism of a mechanical memory of the intracelualr forces and structures with consideration for cell aging. We used vascular smooth muscle cells and found that cell aging increased cell projected area while it reduced intracellular tension and migration ability. We further found that tensional memory of actin stress fibers in vascular smooth muscle cells tended to decrease with cell aging. These results indicate that cell aging not only affects cell morphology and biochemical functions but also mechanical propeties of cells involving in cellular mechanotransduction.

Free Research Field

細胞バイオメカニクス