Multi-level analysis of ischemic heart disease pathology based on heterogeneity in mechano-electric coupling

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K12878
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Okayama University
• Principal Investigator: Iribe Gentaro 岡山大学, 医歯薬学総合研究科, 准教授 (90284885)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 虚血性心疾患 / 心筋メカニクス / 不均一性

Outline of Final Research Achievements

Myocardial cellular function is different between endocardial and epicardial cells. It is not clear how ischemic condition affects this transmural heterogeneity. In the present study, we isolate the cells from epicardium and endocardium to compare the response of their mechanical properties to stretch. We found that ischemic condition reduces the transmural heterogeneity in the response to stretch. The present findings may provide new insight into pathophysiology of ischemic heart disease.

Free Research Field

心臓生理学