Development of a micro RI dynamic imaging system for living cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K12886
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: Yamaya Taiga 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 計測・線量評価部, チームリーダー(定常) (40392245)
• Co-Investigator(Kenkyū-buntansha): 金子 純一 北海道大学, 工学研究院, 准教授 (90333624)
• Co-Investigator(Renkei-kenkyūsha): NISHIKIDO Fumihiko 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所, 研究員 (60367117) ; NAKANISHI Takayuki 北海道大学, 工学(系)研究科(研究院), 助教 (30609855)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 核医学 / PET

Outline of Final Research Achievements

Studies on cell regulation are attracting worldwide attention in order to realize regenerative medicine. Therefore, a nuclear medicine imaging method, which can use tracers having substantially the same composition as a target biomolecule, is required. In this research, we developed a nuclear medicine imaging system for dynamic cell observation. Specifically, in order to prevent broadening of the scintillation position because of scintillation light spreading in the scintillator, beta-rays are detected by a thin scintillator plate. A scientific CMOS camera with low readout noise and high resolution was used to detect scintillation light. The scintillator plate was a CsI crystal (150 micron thick) connected to an optical fiber (6 micron diameter) array. The scintillation light generated from the scintillator plate was extracted through optical fibers. Imaging results showed that our system has sufficient sensitivity for imaging uptake of fluorodeoxyglucose by single cells.

Free Research Field

核医学物理