2017 Fiscal Year Final Research Report
Study on novel diagnostic approach for early detection and early treatment of staphylococcus aureus infectious disease
| Project/Area Number |
16K12912
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical systems
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 黄色ブドウ球菌 / 感染症 / 病原性発現 / 早期発見 / 早期治療 / 数理解析 / 揺らぎ / 状態遷移 |
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| Outline of Final Research Achievements |
The pathogenic expression process of Staphylococcus aureus (S.aureus) was mathematically analyzed by employing numerical simulation techniques. The pathogenic gene expression level showed a significant fluctuation in the late incubation period. From a perspective of biophysics, the increasing in fluctuation was identified a presymptom of pathogenic expression. Moreover, an inhibition of the fluctuation arrested the pathogenic expression. The realization of the inhibition could contribute to a development of novel therapeutic system which maintains S.aureus in bacteriostatic condition.
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| Free Research Field |
システム生物学、医用工学
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