Novel physiological role in secreted protein by psycho-social stress

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K13030
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: The University of Tokushima
• Principal Investigator: SHIUCHI Tetsuya 徳島大学, 大学院医歯薬学研究部(医学系), 准教授 (70372729)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 心理社会的ストレス / エネルギー代謝 / 行動

Outline of Final Research Achievements

I examined the physiological mechanism of secreted protein by psycho-social stress in mice. Male C57BL/6J mice given by social defeat stress showed social avoidance behavior with increase plasma level of protein "F", which was an important cytokine for energy expenditure. Exhaustive analysis revealed that mRNA expression of "F" was increased in liver, and that beta-adrenaline blocker inhibited protein "F" secretion under the stress. These results suggest that psycho-social stress secreted protein "F" from liver by sympathetic nerve activation or adrenaline in mice.

Free Research Field

生理学