Development of near infrared dyes for photoacoustic imaging

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K13097
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Chemical biology
• Research Institution: Nagoya University
• Principal Investigator: TAKI Masayasu 名古屋大学, 物質科学国際研究センター(WPI), 特任准教授 (70378850)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 近赤外色素 / 光音響イメージング

Outline of Final Research Achievements

A series of polymethine NIR dyes containing a cyclic thioester moiety as a molecular probe for photoacoustic imaging. A cationic polymethine dye with dimethylaminophenyl groups on both sides exhibited an absorption maximum at 903 nm in CH2Cl2, whereas a dye substituted with julolidinyl groups showed longer absorption wavelength, indicating that these are promising NIR dyes for photoacoustic imaging. In order to evaluate the photoacoustic properties of these dyes, an optical system was established. In fact, using gold nanoparticles, it was found that the photoacoustic signal intensities increased with increasing the concentration of gold nanoparticles. The comparison of photoacoustic signals between dimethylaminophenyl and julolidinyl derivatives demonstrated that the latter afforded stronger signals when dyes in CH3CN were irradiated with a femto-second pulsed laser at 800 nm.

Free Research Field

ケミカルバイオロジー