2017 Fiscal Year Final Research Report
Evaluation of abnormalities of brain semantic network in schizophrenia
| Project/Area Number |
16K13106
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic / Social brain science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
西本 伸志 国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター脳情報通信融合研究室, 主任研究員 (00713455)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 統合失調症 / fMRI |
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| Outline of Final Research Achievements |
The whole brain activity during movie watching was continuously recorded from schizophrenia patients and healthy controls by 3T fMRI. A coefficient matrix (word vector in the brain) was obtained from time series of nouns included in the movie and brain activity data. The matrix illustrates the relationship between regional brain activity and combination of nouns. For this brain word vector, network analysis using graph theory was applied. Compared with healthy subjects, a categorical structure was disorganized in the brain semantic network, and the relationship between the superordinate concept and the subordinate concept was also unnatural in schizophrenia.
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| Free Research Field |
精神医学
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