Active control of nanopore translocation of nanoparticles and biomolecules

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K13645
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nanobioscience
• Research Institution: Keio University
• Principal Investigator: SAIKI Toshiharu 慶應義塾大学, 理工学部(矢上), 教授 (70261196)
• Co-Investigator(Renkei-kenkyūsha): KUWAHARA Masashi 国立研究開発法人産業技術総合研究所, 電子光技術研究部門, 上級主任研究員 (60356954)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: バイオセンシング / ナノポア / 相変化材料

Outline of Final Research Achievements

Applications of nanopore technology are not limited to the DNA sequencing but also are extending to the molecular recognition, protein analysis, cell imaging, and gene transfer. The objective of this study is to implement active functionalities into the solid-state nanopore by employing a phase-change material. A huge contrast of optical indices between the crystalline and amorphous phases of phase-change material enabled control of convection flow and thermophoresis in the vicinity of nanopore by means of light irradiation. Switching of nanopore translocation of DNA molecules and nanoparticles was demonstrated.

Free Research Field

ナノフォトニクス・光物性・バイオセンシング