Experimental and mathematical models of collective motion - for the understanding of migrating cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K13866
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biological physics/Chemical physics/Soft matter physics
• Research Institution: Tokyo University of Science
• Principal Investigator: Yutaka Sumino 東京理科大学, 理学部第一部応用物理学科, 講師 (00518384)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 自己駆動粒子 / パターン形成 / 細胞運動 / 細胞変形

Outline of Final Research Achievements

The aim of this project is to model collective behavior of cell moving on a substrate. As a method, we used non-biological experimental model as well as mathematical model. We found that shape of excluding volume, competition between conservative and non-conservative force, transition of particle condition, can be relevant components affecting on collective motion in an experimentally tractable manner.
Our experimental as well as mathematical model showed that the collective motion of elements that is coupled though diffusion field will be an interesting class, in which competition between conservative and non-conservative force appears. Our experimental model system developed in this project, droplet and particle moving on a water surface, and polystyrene particle moving under alternating electric field, will be candidates for models to reproduce collective behavior of cells interacting though diffusion field.

Free Research Field

非平衡ソフトマター物理