2017 Fiscal Year Final Research Report
Catalytic Syntheses of Fluorine-Containing Compounds via Fluorine-Substituted Transition Metal Carbene Complexes
| Project/Area Number |
16K13943
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 触媒 / フッ素 / カルベン錯体 / ニッケル / 銅 / 医薬 / 農薬 |
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| Outline of Final Research Achievements |
Fluorine-containing compounds have increased their importance as pharmaceuticals and agrochemicals especially in recent years. We have focused our attention on difluorocarbene complexes that would realize highly efficient syntheses of organofluorine compounds with metal catalysts. We disclosed that nickel(II) and copper(I) complexes generated the corresponding difluorocarbene complexes and that selective syntheses of isomeric α,α- and β,β-difluorocyclopentanone derivatives were facilitated starting from common silyl dienol ethers. The structures that we successfully constructed in this project are ubiquitously found in biologically active compounds, which leads to development of pharmaceuticals and agrochemicals.
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| Free Research Field |
有機合成化学
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