2017 Fiscal Year Final Research Report
Selective Recognition of Biomolecules by Molecular Capsules
| Project/Area Number |
16K13947
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 金属 / 芳香環 / 分子カプセル / 生体分子 / 糖 |
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| Outline of Final Research Achievements |
Selective recognition of saccharides by artificial receptors in water is a challenging goal due to their strong hydrophilicities and complex molecular structures with subtle regio- and stereochemical differences. Here we report the selective and efficient encapsulation of D-sucrose within a coordination-driven molecular capsule from natural saccharide mixtures in water (~100% selectivity and >85% yield). Unlike previous artificial receptors and natural receptors that rely on multiple hydrogen-bonding interactions, theoretical calculations and control experiments indicate that the observed unique selectivity arises frommultiple CH-pi interactions between the sucrose hydrocarbon backbone and the shape-complementary polyaromatic cavity (~1 nm in diameter) of the capsule.
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| Free Research Field |
錯体化学
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