Development of innovative molecular devices based on molecular inclusion reaction

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K13961
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Inorganic chemistry
• Research Institution: Nagoya University
• Principal Investigator: Yamada Yasuyuki 名古屋大学, 物質科学国際研究センター, 准教授 (10385552)
• Research Collaborator: Itoh Ryosuke ; Ogino Sayaka ; Mihara Nozomi ; Nawate Katsuhiko ; Maeno Tomoaki ; Furukawa Ko ; Kato Tatsuhisa ; Akine Shigehisa ; Sugimoto Kunihisa ; Shimokawa Koya ; Igawa Kazunobu ; Tomooka Katsuhiko ; Tanaka Kentaro
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: ポルフィリン / フタロシアニン / ロタキサン / 分子機械

Outline of Final Research Achievements

We synthesized a multiply interlocked molecular assembly (M) with a novel topological structure in which a cofacial porphyrin dimer connected with four alkylammonium chains is quadruply interlocked by a phthalocyanine bearing four peripheral crown ethers. Since M has such a flexible structure that an alternative addition of an appropriate acid and a base resulted in its dynamic conformational change. It was demonstrated that M incorporates π-planer anions in its two isolated nanospaces in between a porphyrin and a phthalocyanine. It was also found that M showed unique molecular inclusion behavior in which a central phthalocyanine moves like a “slide door” to capture a guest molecule. This behavior is quite similar to the “induced fit” found in natural enzymes.

Free Research Field

超分子化学、錯体化学

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は主に以下の２つである。(i)これまでにないトポロジーを有する多重インターロック型ポルフィリン・フタロシアニン分子組織を構築し、その構造変化特性を明らかにした点。(ii)この分子組織がその柔軟かつユニークな構造を利用して、天然の酵素の「induced fit」に類似した分子認識様式を示すことを明らかにした点。特に、この分子組織はinduced fit型の分子認識を示す初めての人工ホスト分子の合成例であり、その設計原理を明らかにした点でその学術的意義は大きいと言える。