2017 Fiscal Year Final Research Report
Single-molecule detection of glucose based on conductance measurements using molecular tips
| Project/Area Number |
16K14018
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Analytical chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 分子探針 / 走査型トンネル顕微鏡 / 単分子接合 / グルコース / 超分子化学 |
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| Outline of Final Research Achievements |
In the present research project, we developed a novel method for single-molecule detection of glucose. The detection is achieved through the simple rapid measurements of conductance for a single-molecule junction containing the analyte. Since the methodology developed in the present work allows for extremely sensitive detection of glucose, the blood glucose monitoring using saliva, which contains glucose in a low concentration compared with blood, would become possible. This opens up a way for realizing technology for glucose monitoring in a non-invasive way without blood sampling. Furthermore, the present measurement protocol is suitable for miniaturization and cost reduction of the analytical device. Consequently, the methodology contributes to the decrease in physical and economic burden for diabetic patients toward enhancing the quality of life.
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| Free Research Field |
分析化学
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