Determination of potential health risks of bioactive chemicals in reclaimed water

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14051
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Green/Environmental chemistry
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Kim Sung Bae 国立研究開発法人産業技術総合研究所, 環境管理研究部門, 主任研究員 (60470043)
• Research Collaborator: FUJII Rika 国立研究開発法人産業技術総合研究所, 環境管理研究部門 ; WU Qian-Yuan 清華大学, 深圳研究生院
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 再生水 / 生物発光 / 発光プローブ / イメージング / 化学物質 / ホルモン様活性 / 毒性 / 生理活性

Outline of Final Research Achievements

During the period, the researchers conducted a series of studies on colorimetrical technology for determining unexpected, potential risk factors of man-made chemicals in reclaimed water. First, divalent cations in reclaimed water were colorimetrically examined with cation-sensitive artificial luciferases (ALucs), which was originally developed the researchers. Further, we determined (i) the male and female sex hormone-like activities and the antagonistic effects, and (ii) teratogenicity of man-made chemicals in reclaimed water. The study revealed that some chemicals have a synergetic effect by combining with other chemicals, although they are poor in the antagonistic activity to female sex hormones. A new luminescent probe was also developed for determining immunotoxicity of chemicals in reclaimed water. We published 8 science journals and conducted 6 presentations in academic society meetings.

Free Research Field

分析化学、環境科学