Development of in vivo measurement of drug permeation and enhancement of transdermal drug delivery

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14150
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Fluid engineering
• Research Institution: Tohoku University
• Principal Investigator: Kikuchi Kenji 東北大学, 工学研究科, 准教授 (00553801)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 経皮吸収促進 / 薬剤浸透 / in vivo計測 / 二光子顕微鏡 / 機械的刺激

Outline of Final Research Achievements

To control a drug permeation from the skin surface, a three dimensional skin structure and precise drug permeation measurements are needed. We measured non-invasively the three dimensional skin structure by using a two photon microscopy and the drug permeation through the skin surface by using a confocal microscopy. As our results, the qualitative measurements of the strain of skin surface and the amount of permeated drug through the skin were succeeded. We found the mechanism of drug permeation through the skin surface with the skin extension.

Free Research Field

生体流体工学