Challenge of Noninvasive Quality Evaluation of Oocyte Using Quartz-crystal Resonating MEMS Probe

2016 Fiscal Year Final Research Report

• Project/Area Number: 16K14195
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Intelligent mechanics/Mechanical systems
• Research Institution: Nagoya University
• Principal Investigator: Arai Fumihito 名古屋大学, 工学研究科, 教授 (90221051)
• Project Period (FY): 2016-04-01 – 2017-03-31
• Keywords: マイクロ・ナノデバイス / 超精密計測 / マイクロマシン / 走査プローブ顕微鏡 / 細胞・組織

Outline of Final Research Achievements

In this research, force sensing system of oocyte is designed and evaluated by using the quartz-crystal resonating MEMS probe. The vibration induced flow is used to control position and orientation of oocyte. The vibration induced flow is composition of steady flow and unsteady flow. The flow is investigated and the effect of unsteady flow is evaluated by analysis and experiment. Also, the quartz-crystal resonating MEMS probe is designed to have high sensitivity and high rigidity, and the force sensing probe with wide measurement range was developed. With this prove, mechanical property of the spheroid was measured and evaluated. This system is applicable to the measurement of mechanical property of different cells as well as oocyte. Moreover, based on the force measurement of oocyte, Young’s modulus of zona pellucida is measured and evaluated for the quality measure.

Free Research Field

知能機械学・機械システム