A study on correlation between red blood cell aggregation measured by ultrasound scattering property due to blood flow cessation and diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14272
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Measurement engineering
• Research Institution: Tohoku University
• Principal Investigator: Kanai Hiroshi 東北大学, 工学研究科, 教授 (10185895)
• Co-Investigator(Kenkyū-buntansha): 瀧 宏文 東北大学, 医工学研究科, 非常勤講師 (40467460) ; 石垣 泰 岩手医科大学, 医学部, 教授 (50375002)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 超音波後方散乱特性 / 赤血球凝集度 / 糖尿病 / 血液性状 / 血糖値 / 医用超音波 / 高周波超音波 / 手背静脈

Outline of Final Research Achievements

In the present study, we evaluated the degree of Red Blood Cell (RBC) aggregation at a low shear rate robustly by introducing new two parameters determined from changes in the scattering power spectrum of the echoes from the intravascular lumen before and after cessation of blood flow. We also considered the clinical significance of these parameters and the change in sizes estimated in the previous method by comparing them with the blood glucose level obtained just before the ultrasonic measurements. We applied the measurements on one healthy subject and 11 diabetic patients. The correlation was obtained between one of the proposed parameters and the blood glucose level. However, the p value was not so high and one of the reasons for the decline of the correlation will be that some factors other than blood glucose also affect the RBC aggregation. Thus, the proposed method has a potential in clinical applications by figuring out the various factors affecting RBC aggregation.

Free Research Field

医用超音波工学