Magnetic-field assisted binding method between magnetic markers and targets for biomedical applications

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14277
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Measurement engineering
• Research Institution: Kyushu University
• Principal Investigator: ENPUKU Keiji 九州大学, 超伝導システム科学研究センター, 教授 (20150493)
• Co-Investigator(Kenkyū-buntansha): 吉田 敬 九州大学, システム情報科学研究院, 准教授 (30380588)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 磁気マーカー / ブラウン運動 / バイオセンシング / 磁気粒子イメージング / 磁気的ハイパーサーミア

Outline of Final Research Achievements

We have developed a new binding method between magnetic markers and targets for biomedical applications. In this method, magnetic field is applied during the binding reaction so as to prevent the Brownian rotation of the markers in solution. As a result, magnetic moments of all the bound markers can be aligned in the direction of applied field. First, we determine the strength of the magnetic field that is necessary to align the magnetic moment. Next, we show that the magnetic properties of the bound markers, such as harmonic spectra and hysteresis loss, are significantly improved with this method. Finally, we apply the method to improve the performance of biosensing using magnetic markers.

Free Research Field

計測工学