2017 Fiscal Year Final Research Report
Elucidation of virus disinfection mechanism and disinfection resistance mechanism by analysis of viral capsid protein with mass spectrometry
| Project/Area Number |
16K14325
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Civil and environmental engineering
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 水系感染症ウイルス / 消毒耐性ウイルス / 熱処理 / 塩素処理 / 感染性評価手法 / PCR法 / PMAxx-Enhancer-PCR法 / 消毒不活化メカニズム |
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| Outline of Final Research Achievements |
The objective of this study was to elucidate the virus disinfection mechanism and the disinfection resistance mechanism by analysis of damage of viral capsid protein constituting virus particles. As a result, it was revealed that the damage of the capsid protein is the main cause of inactivation of adenovirus, coxsackievirus and pepper mild mottle virus in heat treatment. In contrast, it was suggested that not only the damage of the capsid protein but also mild oxidation and/or chlorination of the capsid protein probably contribute to inactivation of those viruses in chlorine treatment.
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| Free Research Field |
水環境工学，水処理工学
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