Development of Physiologically Based Pharmaco-kinetic model for Computer Simulated Person

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14346
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Architectural environment/Equipment
• Research Institution: Kyushu University
• Principal Investigator: Ito Kazuhide 九州大学, 総合理工学研究院, 教授 (20329220)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 生理的薬物動態モデル / 数値人体モデル / 経気道暴露 / 経皮曝露 / 計算流体力学

Outline of Final Research Achievements

Indoor air quality (IAQ) has a potential impact on human health and thus a precise prediction method of the interaction between the IAQ and the human body has been recognized as a preferential research issue worth dealing with. Especially, from the viewpoint of risk assessment of respiratory exposure, it is necessary to estimate a quantitative effect of inhaled contaminants on the human body. In this case, physiologically-based pharmacokinetic (PBPK) model for the prediction of drug/contaminant transport phenomenon inside the human body would be useful.
In this study, we developed PBPK model for inhalation exposure analysis that is able to integrated Computer Simulated Person (CSP for computational fluid dynamics (CFD). Furthermore, we performed a PBPK-CFD hybrid analysis using the CSP, i.e., PBPK-CFD-CSP hybrid analysis, under various indoor environmental conditions. Finally, we demonstrated the potency of the proposed PBPK-CFD-CSP analysis method.

Free Research Field

建築環境・設備