2016 Fiscal Year Final Research Report
Mechanisms of neuronal cell death and survival
| Project/Area Number |
16K14567
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HONDA Takao 慶應義塾大学, 医学部, 講師 (30365225)
KUBO Ken-ichiro 慶應義塾大学, 医学部, 講師 (20348791)
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| Project Period (FY) |
2016-04-01 – 2017-03-31
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| Keywords | 神経科学 / 脳・神経 / 発生・分化 / 細胞死 |
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| Outline of Final Research Achievements |
We found that massive neuronal cell death occurred during culture of mouse cerebral cortex and that a certain component in the culture medium was important for this cell death induction. We have therefore analyzed the mechanism of this cell death, and have discovered a drug that could prevent the cell death by inhibiting this mechanism.
We have also identified a set of genes whose expression was changed dramatically when mouse embryos had been exposed to transient ischemia.
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| Free Research Field |
発生神経生物学
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